Shifang Shan

This paper introduces a Dual-NIR Switch using near-infrared light to control neuronal activity in mice without sustained illumination, enabling on-demand neuromodulation.

This paper develops ProAPOBECs, engineered cytidine deaminases fused with PUF proteins, for effective RNA base editing in the brain, correcting mutations and reducing autistic-like behaviors in mice.

This study shows that Srcap haploinsufficiency in mice causes autistic-like behaviors by reducing Satb2 expression, which can be reversed with Satb2 gene therapy.

This paper demonstrates whole-brain in vivo base editing in mice to reverse autistic-like behaviors by correcting a mutation in the MEF2C gene.

This study identifies a SENP1 mutation in mice that causes core autistic-like symptoms by disrupting the SENP1-FMRP axis in the retrosplenial agranular cortex.

This study identifies CNTNAP3 mutations in ASD cohorts and shows its role in synaptic development and social behavior in mice.

This study shows that CREST mutations in mice lead to neuroinflammatory responses and motor defects similar to ALS, revealing a molecular mechanism involving the CREST-BRG1 complex and cytokine expression.