Author

Ann Le

Population Health Research Institute

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Assay:scRNA-seq· 2 Research Focus:variant effect prediction· 2 Approach:contrastive learning· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Berk TurhaniD· 2 shared Danwei HuangfuiD· 2 shared Guillaume ParéiD· 2 shared Hanbyul Lee· 2 shared Kushal K. DeyiD· 2 shared Ricky LaliiD· 2 shared Alice ManiD· 1 shared Arghavan Omidi· 1 shared

Activity by Year

2021-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersGenetics

Berk TurhanORCID

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Author profile →

4 papers

Recent·Most cited

Perturbation-induced gene programs map the hidden regulatory architecture of complex diseases

Berk Turhan, Hanbyul Lee, Dingyu Liu, Ann Le, Arpan Ghosh, Dhruba Nandi, Rahul Mazumder, Jesse M. Engreitz, Xin Jin, Danwei Huangfu, Kushal K. Dey

This paper introduces Perturbscape, a framework that uses perturbation-induced gene programs to identify disease-relevant genes and pathways, showing higher heritability informativeness than steady-state approaches.

bioRxiv · Nov 4, 2026 · PreprintGenetics

A dish-to-biobank framework links β-cell nutrient-stress programs to genetic and dietary risk for Type 2 Diabetes

Xianming Wang, Hanbyul Lee, Ann Le, Berk Turhan, Nan Hu, Pretty S. Garcia, Xuewei Cao, D K Liu, Thahmina A. Ali, Nan Zhang, Breanna Williams, Caleb A. Lareau, G M Wang, Danwei Huangfu, Kushal K. Dey

bioRxiv · Jun 16, 2026 · PreprintGenetics

Biobank-scale survey of gene-diet interactions informs precision nutrition polygenic scores

Matteo Di Scipio, Alice Man, Ricky Lali, Jianhan Wu, Ann Le, Paul W. Franks, G P Pare

The paper assesses gene-diet interactions in UK Biobank data to derive polygenic scores that associate with cardiometabolic outcomes and clinical conditions like gout.

medRxiv · Apr 20, 2026 · PreprintGenetic & Genomic Medicine

Calibrated rare variant genetic risk scores for complex disease prediction using large exome sequence repositories

Ricky Lali, Michael Chong, Arghavan Omidi, Pedrum Mohammadi‐Shemirani, Ann Le, Edward Cui, Guillaume Paré

The paper develops a method to create calibrated rare variant genetic risk scores using exome data, showing strong association with coronary artery disease risk.

Nature Communications · Oct 6, 2021Peer-reviewedGenetics