Author

Hanbyul Lee

Memorial Sloan Kettering Cancer Center

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Research Focus:gene regulatory network inference· 3 Organism:human· 3 Assay:scRNA-seq· 2 Approach:statistical model· 2 Research Focus:cell-cell communication· 1 Approach:contrastive learning· 1 Research Focus:database / resource· 1

Frequent Co-Authors

Kushal K. DeyiD· 3 shared Ann Le· 2 shared Berk TurhaniD· 2 shared Danwei HuangfuiD· 2 shared Gao T. WangiD· 2 shared Rahul MazumderiD· 2 shared Xin JiniD· 2 shared Xuewei CaoiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersGenetics

Kushal K. DeyORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Perturbation-induced gene programs map the hidden regulatory architecture of complex diseases

Berk Turhan, Hanbyul Lee, Dingyu Liu, Ann Le, Arpan Ghosh, Dhruba Nandi, Rahul Mazumder, Jesse M. Engreitz, Xin Jin, Danwei Huangfu, Kushal K. Dey

This paper introduces Perturbscape, a framework that uses perturbation-induced gene programs to identify disease-relevant genes and pathways, showing higher heritability informativeness than steady-state approaches.

bioRxiv · Nov 4, 2026 · PreprintGenetics

A dish-to-biobank framework links β-cell nutrient-stress programs to genetic and dietary risk for Type 2 Diabetes

Xianming Wang, Hanbyul Lee, Ann Le, Berk Turhan, Nan Hu, Pretty S. Garcia, Xuewei Cao, D K Liu, Thahmina A. Ali, Nan Zhang, Breanna Williams, Caleb A. Lareau, G M Wang, Danwei Huangfu, Kushal K. Dey

bioRxiv · Jun 16, 2026 · PreprintGenetics

Mapping disease critical spatially variable gene programs by integrating spatial transcriptomics with human genetics

Hanbyul Lee, Haochen Sun, Xuewei Cao, Berke Karaahmet, Zhijian Li, Hans Ulrich-Klein, Mariko F. Taga, Gao T. Wang, Philip L. De Jager, David Alan Bennett, Luca Pinello, Xin Jin, Rahul Mazumder, Kushal K. Dey

Spacelink integrates spatial transcriptomics with genetics to identify spatially variable genes linked to disease, showing improved detection power and disease informativeness.

bioRxiv · Sep 24, 2025 · PreprintGenomics