Ann Titus

A multi-organ spatial metabolomic atlas of exercising mice reveals neuronal Complex I as a convergent and sufficient axis for tau pathology reduction in PS19

This paper constructs a spatial metabolomic atlas of exercise in mice, identifies Complex I as a key target for reducing tau pathology, and shows that enhancing its activity mimics exercise's protective effects.

Metabolic Coherence of the Mouse Brain

The paper maps spatial metabolome coherence across mouse brain regions using MALDI imaging and optimal transport, showing preserved coherence in Alzheimer's model despite metabolic changes and demonstrating intervention effects.

AMPK agonism optimizes the in vivo persistence and anti-leukemia efficacy of chimeric antigen receptor T cells

This study shows that activating AMPK during CAR T cell expansion improves their in vivo persistence and anti-leukemia efficacy without altering expansion protocols or genetic constructs.