The liver compensates for zonal loss of glucose 6-phosphatase to prevent glycogen storage disease
Roger J. Liang, Ling Cai, Phong T. Nguyen, Sherwin Kelekar, Margaret Cervantes, Trevor S. Tippetts, Eric Chen, Roberto Ribas, Alison Ryan, JANICE YANG CHOU, Ramon C. Sun, Hao Zhu, Ralph J. DeBerardinis
This study shows that localized loss of G6pc1 in liver zones causes local glycogen accumulation but not systemic disease, highlighting organ-wide compensation for metabolic homeostasis.
bioRxiv · Jul 28, 2026 · PreprintPhysiology