Lei Wu

Genome-wide Analysis of the VQ Gene Family and Expression Profiling in Sorghum bicolor

This study identifies and characterizes VQ genes in sorghum, showing their differential expression and potential roles in salt stress tolerance.

Simultaneous multi-area recordings in macaque frontoparietal cortex during a manual object-interaction task

This paper presents a dataset of neural and kinematic recordings from a macaque performing complex hand-object interactions, showing variation in decoding performance across algorithms and channel availability.

Evaluating Protein Language Model Embeddingsfor Structural Similarity in the Protein-Sequence Twilight Zone

This study evaluates protein language model embeddings for estimating structural similarity in the protein-sequence twilight zone and finds that ProstT5 performs best.

A multi-organ spatial metabolomic atlas of exercising mice reveals neuronal Complex I as a convergent and sufficient axis for tau pathology reduction in PS19

This paper constructs a spatial metabolomic atlas of exercise in mice, identifies Complex I as a key target for reducing tau pathology, and shows that enhancing its activity mimics exercise's protective effects.

Metabolic Coherence of the Mouse Brain

The paper maps spatial metabolome coherence across mouse brain regions using MALDI imaging and optimal transport, showing preserved coherence in Alzheimer's model despite metabolic changes and demonstrating intervention effects.

Oxidation-Driven mtDNA B-Z Transition Activates ZBP1 to Mediate Acetaminophen Hepatotoxicity

This study identifies oxidative mtDNA B-Z transitions activating ZBP1 as a key mechanism in APAP-induced liver failure and shows TH107854 can reverse this process.

ZBP1 Senses Splicing Aberration through Z-RNA to promote Cell Death

This study shows that spliceosome inhibition generates Z-RNA, sensed by ZBP1 to trigger necroptosis in response to splicing aberrations.

Cortical inhibitory parvalbumin interneurons exhibit metabolic specializations coordinated by PGC-1α that are lost in rodents and humans after traumatic brain injury

The paper shows that PV-INs have unique metabolic specializations lost after TBI, which can be rescued by 2-deoxyglucose, and identifies PGC-1α and lncRNAs as key factors in this dysfunction.

MetaVision3D: Automated framework for the Generation of Spatial Metabolome Atlas in 3D

MetaVision3D converts serial 2D MALDI mass spectrometry imaging sections into a 3D spatial metabolome atlas using computer vision techniques.

Spatial Metabolome Lipidome and Glycome from a Single brain Section

The paper presents a method for simultaneous spatial analysis of metabolome, lipidome, and glycome from a single tissue section using mass spectrometry imaging and a computational framework called Sami.