Arthur Liesz

This paper develops MRI-compatible rigid head holders for mice to enable artifact-free multimodal imaging combining intravital microscopy and MRI.

This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.

GluTrooper is a mouse line for whole-brain glutamate imaging with long-lasting sensor expression and multimodal imaging capabilities.

LipiGo is a DNA-lipid nanoparticle hybrid that enables efficient delivery of functional mRNA to non-hepatic tissues, particularly the spleen, through passive redistribution and active targeting.

This paper introduces a quantitative MSI workflow using 13C-labeled yeast extract to enable reliable spatial metabolomics, revealing metabolic changes in the ipsilateral cortex after stroke.

This study identifies innate immune memory after brain injury as a driver of chronic cardiac dysfunction, showing that post-stroke epigenetic changes in myeloid cells lead to inflammation and fibrosis in the heart.

The paper shows pericytes constrict during ischemia, remain constricted post-reperfusion, and contribute to no-reflow, with some surviving and upregulating transcripts, suggesting they are therapeutic targets.

The paper identifies interferon-responsive oligodendrocytes in aging white matter linked to T cells and shows their role in white matter pathology.

This study shows that TREM2 deficiency reduces microglial hyperactivation in GRN-deficient models but does not rescue lysosomal dysfunction or neurodegeneration biomarkers.

This study shows that microbiota-derived short chain fatty acids (SCFA) increase Aβ plaque deposition in Alzheimer's disease by promoting microglial activation and ApoE upregulation.

This study identifies proteomic changes in microglia during Alzheimer's disease progression in mouse models, showing fibrillar Aβ drives microglial dysfunction.

The paper identifies specialized somatic microglia-neuron junctions that enable microglia to monitor and protect neuronal function through purinergic signaling.

This paper introduces an improved widefield calcium imaging protocol for studying interhemispheric connectivity in mice, showing reduced connectivity after stroke and partial recovery over time.

The paper introduces a new imaging technique to enhance fluorescent signal in cleared mouse bodies, enabling whole-body visualization of neuronal connectivity and trauma effects.