Cancer BiologybioRxivPreprint
Co-targeting menin and LSD1 dismantles oncogenic programs and restores differentiation in MLL-rearranged AML
Mina Masoumeh Tayari, Helena Gomes Dos Santos, Felipe Beckedorff…·Justin M. Watts
This study identifies LSD1 as a cofactor of the menin-MLL-LEDGF complex and shows that combining menin and LSD1 inhibition effectively treats MLL-rearranged AML by dismantling oncogenic programs and promoting differentiation.
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