Cell BiologybioRxivPreprint
USP1 deubiquitinates protein kinase Akt to inhibit PI3K-Akt-FoxO signaling
Dana Goldbraikh, Danielle Neufeld, Yara Mutlak-Eid…·Shenhav Cohen
The paper identifies USP1 as a deubiquitinase that inhibits PI3K-Akt-FoxO signaling by removing K63-linked ubiquitin from Akt, contributing to insulin resistance and malignancies.
DOI 10.1101/654921