NeuroscienceBiological PsychiatryPeer-reviewed
Arrestin-3 agonism at D3 dopamine receptors defines a subclass of second generation antipsychotics that promotes drug tolerance
Selin Schamiloglu, Elinor Lewis, Caroline M. Keeshen…·Jennifer Lynne Whistler
This study identifies some second generation antipsychotics (SGAs) as arrestin-3 agonists at D3 dopamine receptors, showing that chronic use leads to receptor degradation and altered drug efficacy.
14 citations