Molecular BiologyJournal of VirologyPeer-reviewed
BET Degraders Reveal BRD4 Disruption of 7SK and P-TEFb is Critical for Effective Reactivation of Latent HIV in CD4+ T-cells
Anne‐Marie W. Turner, Frances M. Bashore, Shane D. Falcinelli…·David M. Margolis
This study shows that BRD4 degraders are less effective than BET inhibitors in reactivating latent HIV in CD4+ T-cells, highlighting the importance of BRD4's role in disrupting 7SK and P-TEFb.
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