Reference-free multiplexed single-cell sequencing identifies genetic modifiers of the human immune response
George C. Hartoularos, Yichen Si, Fan Zhang, Pooja Kathail, David S. Lee, Anton Ogorodnikov, Yang Sun, Yun S. Song, Hyun Min Kang, Chun Ye
The paper introduces clue, a reference-free framework for multiplexed single-cell sequencing to identify genetic modifiers of immune responses using SNP-based clustering and eQTL mapping.
bioRxiv · May 29, 2023 · PreprintGenomics