Gain-of-function mutation in SKAP2 leads to type 1 diabetes and broader autoimmunity through hyperactive integrin signaling in myeloid cells
Courtney M. Tamaki, Chester E. Chamberlain, Clare L. Abram…·Clifford A. Lowell
Author
University of California, San FranciscoORCID 0000-0002-1124-628XUnclaimed ORCID profile · follow to get notified of new preprints
3 papers
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Courtney M. Tamaki, Chester E. Chamberlain, Clare L. Abram…·Clifford A. Lowell
Beatrice Gini, Whitney Tamaki, Johnny X. Yu…·Trever Grant Bivona
This study uses single-cell lineage tracing and RNAseq to identify pre-existing resistant tumor subclones in lung cancer models and their transcriptional programs, revealing mechanisms of therapy resistance.
Byungjin Hwang, David S. Lee, Whitney Tamaki…·Chun Ye
SCITO-seq enables cost-effective profiling of over 10^5 cells using combinatorial indexing with dsc-seq, demonstrating feasibility in mixed cell lines and human lymphocytes.