George C. Hartoularos

This paper introduces PerturbSpace, a method combining CRISPR perturbations with spatially hashed single-cell multiomics to study gene function in tissue architecture.

This study uses single-cell transcriptomics to identify immune dysregulation in JDM, revealing coordinated type I interferon activity and B cell abnormalities.

The paper introduces clue, a reference-free framework for multiplexed single-cell sequencing to identify genetic modifiers of immune responses using SNP-based clustering and eQTL mapping.

SCITO-seq enables cost-effective profiling of over 10^5 cells using combinatorial indexing with dsc-seq, demonstrating feasibility in mixed cell lines and human lymphocytes.

The paper evaluates whether donor-multiplexed scRNA-seq introduces alloreactive gene expression changes and finds no detectable alloreactivity across three workflows.

This study uses single-cell RNA sequencing to analyze Tocilizumab-treated PBMCs, showing reduced inflammatory gene expression in monocytes, supporting its potential to mitigate cytokine storms in COVID-19.

The paper identifies 100 distinct kidney cell clusters using Mux-Seq and scRNA-seq, revealing novel proximal tubular subsets and cell state transitions in the collecting duct.