A cell atlas of human and mouse synovium from early and advanced stages of knee osteoarthritis: BHLHE40 regulates fibroblast activation
Kabriya Thavaratnam, Eric Gracey, Anusha Ratneswaran, Jason S. Rockel, Shabana Vohra, Chiara Pastrello, Flore Stappers, Guillaume Planckaert, Katrina Hueniken, Johana Garcia, Paramvir Kaur, Starlee S. Lively, Pratibha Potla, Carolien Vlieghe, Yoga Raja Rampersaud, , Mohit Kapoor
This study creates a cellular atlas of synovium in human and mouse knee osteoarthritis, identifying BHLHE40 as a key regulator of fibroblast activation and fibrosis.
bioRxiv · Mar 5, 2025 · PreprintMolecular Biology