Dirk Sw Elewaut

This study investigates combining dexamethasone with PPAR agonist GW7647 to improve glucocorticoid efficacy and reduce metabolic side effects in rheumatoid arthritis models.

Mechanical overload activates hypoxia-inducible factor 1-alpha (HIF1a) in tenocytes to drive tendinopathy independently of VEGFA-mediated vascular ingrowth, and tenocyte Hif1a deletion prevents overload-induced tendon degeneration in mice.

This study creates a cellular atlas of synovium in human and mouse knee osteoarthritis, identifying BHLHE40 as a key regulator of fibroblast activation and fibrosis.

This study identifies GDF15 as a mediator of inflammation-associated bone loss via a brain-bone axis, showing it induces bone loss through GFRAL receptor activation in the hindbrain.