TGFB1-Engineered Induced Mesenchymal Stromal Cells Exhibit High Immunomodulatory Potency and Durably Reprogram Synovial Macrophages in Osteoarthritis
Kevin Fan, Mozhgan Rasti, Rebekah Khan, Atoosa Ziyaeyan, Aida Feiz Barazandeh, Rachel Low, Johana Garcia, Shahrzad Nouri, Setareh Safara, Kevin P. Robb, Rajiv A. Gandhi, Sowmya Viswanathan
This study shows that TGFB1-engineered induced MSCs have distinct immunomodulatory effects compared to primary MSCs in an osteoarthritis model.
bioRxiv · Sep 29, 2026 · PreprintImmunology