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Anushka Saha

University of California San Diego

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Synthetic Biology· 1

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Approach:deep learning· 1 Approach:statistical model· 1

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Dario MeluzziiD· 1 shared Dhruva KatrekariD· 1 shared Nathan PalmeriD· 1 shared Prashant MaliiD· 1 shared Yichen XiangiD· 1 shared

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Dario MeluzziORCID

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Synthetic BiologyeLifePeer-reviewedJan 19, 2022

Comprehensive interrogation of the ADAR2 deaminase domain for engineering enhanced RNA base-editing activity, functionality and specificity

Dhruva Katrekar, Nathan Palmer, Yichen Xiang…·Prashant Mali

This study engineers ADAR2 deaminase variants to enhance RNA editing activity, specificity, and functionality through deep mutational scans, domain-wide mutagenesis, and split deaminase design.

51 citations

deep learningstatistical model

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