Changes in perineuronal net and parvalbumin expression in the orbitofrontal cortex of male Wistar rats following repeated fentanyl administration
Mariana I.H. Dejeux, Sarah Jewanee, Samuel Moutos, Arjun Trehan, Melody Golbarani, Joanne Kwak, Evan Farach, Nathan Cheng, Sri V. Kasaram, Aliyah Ogden, Sophia Wright, Benjamin A. Schwartz, Jacques D. Nguyen
This study examines how repeated fentanyl administration affects perineuronal nets and parvalbumin expression in rat orbitofrontal cortex, showing changes in antinociceptive tolerance and PNN/PV correlations.
Frontiers in Neuroscience · Jul 8, 2026Peer-reviewedNeuroscience