Author

Arnab Das

Vrije Universiteit AmsterdamPrimary ORCID profile (0000-0001-7695-5338 · 2 papers)Unclaimed ORCID profile · follow to get notified of new preprints

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Same name, identified by ORCID

Arnab DasiD2 papers · Indian Association for the Cultivation of Science

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Approach:statistical model· 2 Approach:biophysical modeling· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Assay:structural biology· 1

Frequent Co-Authors

Craig E. CameroniD· 3 shared David DuliniD· 3 shared Jamie J. ArnoldiD· 3 shared Thomas K. AndersoniD· 3 shared Flavia Stal PapiniiD· 2 shared John C. MareckiiD· 2 shared Kevin D. RaneyiD· 2 shared Pim P. B. AmericaiD· 2 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

Craig E. CameronORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

RNA virus polymerase-helicase coupling enables rapid elongation throughduplex RNA

Pim P. B. America, Subhas Chandra Bera, Arnab Das, Thomas K. Anderson, John C. Marecki, Flávia S. Papini, Jamie J. Arnold, Kirchdoerfer Robert N., Craig E. Cameron, Kevin D. Raney, Martin Depken, David Dulin

This study shows that the coronavirus helicase enhances RNA synthesis through duplex RNA by tenfold by forming a directional complex with the polymerase, revealing an active coupling mechanism that modulates replication dynamics.

Cell Reports · Apr 1, 2026Peer-reviewedBiophysics

Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir

Asif Rakib, Arnab Das, Subhas Chandra Bera, Pim P. B. America, Misha Klein, Thomas K. Anderson, John C. Marecki, Bing Wang, Eline Bogers, Joy Y. Feng, John P. Bilello, Flavia Stal Papini, Quinte Smitskamp, Jamie J. Arnold, Irina Artsimovitch, , David Dulin

This study shows that coronavirus polymerase template switching is driven by nsp13-helicase and is enhanced by remdesivir and molnupiravir, leading to defective RNA production.

bioRxiv · Oct 3, 2025 · PreprintMicrobiology

The 2'-endo conformation of arabinose-CTP and arabinose-UTP inhibit viral polymerases by inducing long pauses.

Ziyang Xiao, Arnab Das, Abha Jain, Thomas K. Anderson, Craig E. Cameron, Jamie J. Arnold, David Dulin, Robert N. Kirchdoerfer

This study shows that arabinose nucleotides inhibit SARS-CoV-2 and poliovirus polymerases by causing long pauses due to the 2'-endo conformation of the incorporated nucleotides.

bioRxiv · Aug 26, 2025 · PreprintBiochemistry