John P. Bilello

The paper constructs a structural model of coronavirus DMV pore formation and its role in polyprotein processing and replication.

This study shows that coronavirus polymerase template switching is driven by nsp13-helicase and is enhanced by remdesivir and molnupiravir, leading to defective RNA production.

This study shows that oral obeldesivir is effective against RSV infection in African green monkeys, reducing viral load significantly.

This paper describes the discovery and synthesis of GS-7682, a prodrug with broad antiviral activity against RSV and other viruses, showing efficacy in RSV-infected monkeys.

This study investigates how a 4'-cyano modified nucleotide analog inhibits RNA polymerases of respiratory viruses, showing varying efficiency across different viral species.

This study evaluates the antiviral efficacy of GS-5245 against multiple SARS-CoV-2 variants and other coronaviruses, showing broad in vitro activity and protective effects in animal models.

The paper constructs an atomistic model of the SARS-CoV-2 replication-transcription complex, revealing its hexameric structure centered on nsp15 and detailing interactions between viral proteins.