Developmental Plasticity and Stromal Co-option Shape a Pituitary Neuroendocrine Tumor Transcriptional Continuum
Robert C. Osorio, Jun Yeop Oh, Ankita Sati, Jangham Jung, Alexander J. Ehrenberg, Atul Saha, Meeki Lad, Harmon Khela, Nicole Brennick, Petros Giannikopoulos, William W. Seeley, Lea T. Grinberg, Aaron Diaz, Manish Kumar Aghi
This study uses snRNA-seq and spatial transcriptomics to show PitNETs exhibit transcriptional continuity and originate from different developmental pathways, influenced by stromal interactions.
bioRxiv · Jun 18, 2025 · PreprintCancer Biology