Manish Kumar Aghi

This paper demonstrates that a viral vector delivering an IL15 superagonist enhances antitumor immunity and extends survival in glioblastoma models.

This study identifies IL-6 as a driver of immunosuppression in glioblastoma, showing that its inhibition enhances response to immune checkpoint therapy and radiotherapy in preclinical models.

This study identifies dynamic fibroblast-immune interactions that regulate CNS wound healing and neuroinflammation after brain injury.

The paper identifies BIGH3 as a macrophage-secreted driver of GBM invasion using a 3D model and shows its inhibition reduces GSC invasion.

This study uses snRNA-seq and spatial transcriptomics to show PitNETs exhibit transcriptional continuity and originate from different developmental pathways, influenced by stromal interactions.

The paper identifies ACP1 and AURKB as regulators of cortactin-driven actin remodeling in glioblastoma invasion using CRISPRi screens in 3D hydrogels.

The paper investigates neural activity in the human precentral gyrus during speech tasks, finding neurons that encode both listening and speaking phases, including mirror and bridge neurons.

This study shows that high-molecular-weight hyaluronic acid hydrogels promote faster glioblastoma cell invasion with leader-follower dynamics compared to low-molecular-weight HA hydrogels.

This study identifies collagen VI secretion by glioma cells as a mechanism to remodel the microenvironment and promote invasion, particularly in bevacizumab-resistant tumors.

This study develops a xenograft model to study bevacizumab resistance in glioblastoma, finding increased mesenchymal markers and ineffective angiogenic responses across generations.