Aaron A. Diaz

This study uses snRNA-seq and spatial transcriptomics to show PitNETs exhibit transcriptional continuity and originate from different developmental pathways, influenced by stromal interactions.

The paper introduces CLONEID, a framework for organizing clone-resolved data to enable longitudinal genotype-to-phenotype mapping in experiments with repeated molecular and phenotypic measurements.

The paper identifies tumor-wide splicing aberrations that generate public neoantigens, enabling T-cell-based immunotherapies targeting intratumoral heterogeneity.

The paper identifies tumor-specific alternative splicing events in glioma that could generate cell-surface antigens but finds significant spatiotemporal heterogeneity and lack of proteomic evidence.

The paper shows that translation directly regulates chromatin state and transcription in ES cells, with reduced translation causing rapid chromatin changes.