Subcellular Spatial Profiling Unveils Links Between Neuritic Plaques with Selective Tau Vulnerability in Alzheimer's Disease
Huan Li, Elaina R. Gross, Ava Devine, Akhila Gundavelli, Sean A. Prell, Maya E. Woodbury, Lin Gen, Astrid Doering, Aaron Held, Bradley T. Hyman, Alberto Serrano-Pozo, Theodore J Zwang, Rachel E. Bennett, Sudeshna Das
The paper uses subcellular spatial transcriptomics to identify why some neurons in Alzheimer's disease accumulate tau while others resist it, finding differences in molecular programs and neuron-glia interactions.
bioRxiv · Nov 10, 2026 · PreprintNeuroscience