DR5 disulfide bonding as a sensor and effector of protein folding stress
M. E. Law, Z. M. Dulloo, S. R. Eggleston, G. P. Takacs, G. M. Alexandrow, M. Wang, H. Su, B. A. Forsyth, C.-W. Chiang, A. Sharma, S. R. R. Kanumuri, O. A. Guryanova, J. K. Harrison, B. Tirosh, R. K. Castellano, B. K. Law
This study shows that disrupting DR5 disulfide bonds activates pro-apoptotic signaling and reveals DR5 disulfide bonding as a sensor and effector of ER stress in cancer cells.
bioRxiv · Mar 4, 2024 · PreprintCancer Biology