Author

B. A. Krishna

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 4 Research Focus:gene regulatory network inference· 2 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Assay:proteomics· 1

Frequent Co-Authors

C. M. O'Connor· 4 shared A. B. Wass· 2 shared E. G. Elder· 1 shared E. Poole· 1 shared E. Y. Lim· 1 shared G. X. Sedikides· 1 shared J. Sinclair· 1 shared J. Williamson· 1 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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4 shared papersMicrobiology

C. M. O'Connor

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4 papers

Recent·Most cited

Activator protein-1 transactivation of the major immediate early locus is a determinant of cytomegalovirus reactivation from latency

B. A. Krishna, A. B. Wass, C. M. O'Connor

This study identifies AP-1 transactivation of the MIE enhancer as critical for HCMV reactivation from latency, showing its role in de-repressing viral transcripts and downstream genes.

Proceedings of the National Academy of Sciences · Aug 11, 2020Peer-reviewedMicrobiology

The Requirement For US28 During Cytomegalovirus Latency Is Independent Of US27 And US29 Gene Expression

B. A. Krishna, A. B. Wass, R. Sridharan, C. M. O'Connor

This study shows US28 is required for HCMV latency, independent of US27 and US29 gene expression, using mutant viruses in hematopoietic cells.

bioRxiv · Jan 19, 2020Microbiology

Interferon-responsive genes are targeted during the establishment of human cytomegalovirus latency

E. G. Elder, B. A. Krishna, J. Williamson, E. Y. Lim, E. Poole, G. X. Sedikides, C. M. O'Connor, M. Wills, P. J. Lehner, J. Sinclair

This study identifies that US28 downregulates interferon-inducible genes during HCMV latency, with IFI16 suppression enhancing viral gene expression via NF-κB.

bioRxiv · Oct 4, 2019Microbiology

The human cytomegalovirus G-protein coupled receptor US28 promotes latency by attenuating c-fos

B. A. Krishna, M. S. Humby, W. E. Miller, C. M. O'Connor

This paper shows that the HCMV-encoded US28 receptor promotes latency by reducing c-fos expression and AP-1 binding to the MIEP.

bioRxiv · Oct 3, 2018Microbiology