J. Sinclair

Cardiovascular symptoms of PASC are associated with trace-level cytokines that affect the function of human pluripotent stem cell derived cardiomyocytes

This study identifies trace-level cytokines in PASC patients linked to cardiovascular symptoms and shows their impact on cardiomyocyte function using nanotechnology detection.

Discovery of active mouse, plant and fungal cytochrome P450s in endogenous proteomes and upon expression in planta.

The paper identifies active cytochrome P450s in mouse, plant, and fungal systems using chemical probes and mass spectrometry, showing their subcellular localization and activity-based labeling.

Upscaling biodiversity monitoring: Metabarcoding estimates 31,846 insect species from Malaise traps across Germany

The paper demonstrates a cost-effective DNA metabarcoding workflow for large-scale insect biodiversity monitoring, estimating 31,846 species from Malaise trap samples across Germany.

Interferon-responsive genes are targeted during the establishment of human cytomegalovirus latency

This study identifies that US28 downregulates interferon-inducible genes during HCMV latency, with IFI16 suppression enhancing viral gene expression via NF-κB.

Human IL-2 receptor β mutations associated with defects in immunity and peripheral tolerance

This study identifies IL-2Rβ gene mutations causing immune and tolerance defects, showing variable expression impacts on T and NK cells and informing IL-2-based therapies.

Defining the Transcriptional Landscape during Cytomegalovirus Latency with Single-Cell RNA Sequencing

This study uses single-cell RNA sequencing to analyze HCMV latency and finds no evidence of a restricted latency-associated gene expression program, instead showing gene expression patterns similar to late lytic stages at lower levels.