Author

B. Amati

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Assay:bulk RNA-seq· 4 Research Focus:cancer & tumor microenvironment· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

A. Verrecchia· 4 shared M. Doni· 4 shared M. Filipuzzi· 4 shared A. Sabo· 3 shared P. Nicoli· 3 shared A. Bisso· 2 shared A. Boletta· 2 shared D. Olivero· 2 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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4 shared papersCancer Biology

A. Verrecchia

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5 papers

Recent·Most cited

Oxidative stress potentiates the therapeutic action of a mitochondrial complex I inhibitor in MYC-driven B-cell lymphoma

G. Donati, P. Nicoli, A. Verrecchia, V. Vallelonga, O. Croci, S. Rodighiero, M. Audano, L. Cassina, A. Ghsein, G. Binelli, A. Boletta, N. Mitro, B. Amati

This study shows that combining a mitochondrial complex I inhibitor with oxidative stress inducers enhances the killing of MYC-driven lymphoma cells.

bioRxiv · Jun 21, 2022 · PreprintCancer Biology

Polycomb Group Ring Finger Protein 6 suppresses Myc-induced lymphomagenesis

N. Tanaskovic, M. Dalsass, G. Ceccotti, M. Filipuzzi, A. Verrecchia, P. Nicoli, M. Doni, D. Olivero, D. Pasini, H. Koseki, A. Sabo, A. Bisso, B. Amati

This study shows that Pcgf6 loss accelerates Myc-induced lymphomagenesis in mice, despite no impact on transcriptional profiles.

bioRxiv · Dec 2, 2021Cancer Biology

Targeting mitochondrial respiration and the BCL2 family in MYC-associated B-cell lymphoma

G. Donati, M. Rava, M. Filipuzzi, P. Nicoli, L. Cassina, A. Verrecchia, M. Doni, S. Rodighiero, F. Parodi, A. Boletta, C. P. Vellano, J. R. Marszalek, G. Draetta, B. Amati

This paper identifies OxPhos as a key MYC-driven process in DLBCL and shows that targeting ETC complex I with IACS-010759 synergizes with BCL2 inhibitors to kill lymphoma cells.

bioRxiv · Nov 22, 2020Cancer Biology

Cooperation between MYC and β-catenin in liver tumorigenesis requires Yap/Taz

A. Bisso, M. Filipuzzi, G. P. Gamarra Figueroa, G. Brumana, F. Biagioni, M. Doni, G. Ceccotti, N. Tanaskovic, M. J. Morelli, V. Pendino, F. Chiacchiera, D. Pasini, D. Olivero, S. Campaner, A. Sabo, B. Amati

This study shows that Yap/Taz mediate the cooperation between MYC and β-catenin in liver tumorigenesis, identifying a prognostically significant gene signature in human hepatocellular carcinomas.

bioRxiv · Oct 25, 2019Cancer Biology

An early Myc-dependent transcriptional program underlies enhanced macromolecular biosynthesis and cell growth during B-cell activation

A. Tesi, S. De Pretis, M. Furlan, M. Filipuzzi, M. J. Morelli, A. Andronache, M. Doni, A. Verrecchia, M. Pelizzola, B. Amati, A. Sabo

This study identifies a Myc-dependent transcriptional program in activated B-cells that drives macromolecular biosynthesis and cell growth, also found in B-cell lymphomas.

bioRxiv · Mar 4, 2019Cancer Biology