Epidermal Growth Factor Receptor Inhibition Prevents Caveolin-1-dependent Calcifying Extracellular Vesicle Biogenesis
A. B. Nik, H. H. Ng, P. Sun, F. Iacoviello, P. R. Shearing, S. Bertazzo, D. Mero, B. B. Khomtchouk, J. D. Hutcheson
This study shows EGFR inhibition reduces vascular calcification by blocking CAV1-dependent calcifying EV release in CKD mice and humans.
bioRxiv · Nov 8, 2021 · PreprintPathology