P. Sun

Spatial organization of PI3K-PI(3,4,5)P3-AKT signaling by focal adhesions

This study identifies focal adhesions as the subcellular hubs organizing PI3K-PI(3,4,5)P3-AKT signaling, showing localized lipid production and AKT activation, and demonstrates that combined inhibition of PI3K and FAK enhances cancer cell suppression.

Inhibitor of cardiolipin biosynthesis-related enzyme MoGep4 confers broad-spectrum anti-fungal activity

The paper identifies MoGep4 as a key enzyme in cardiolipin biosynthesis in M. oryzae, showing that its inhibitor AXD has broad-spectrum antifungal activity against plant pathogens.

One-pot virus detection based on isothermal amplificationcoupled with temperature-activated argonaute

This paper develops a one-step virus detection method using immobilized thermotolerant Ago to separate amplification and cleavage steps, achieving high sensitivity and specificity.

Geranylgeranyl pyrophosphate (GGPP) is associated with hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4

This study shows GGPP promotes hepatic lipid accumulation and insulin resistance in MAO by prenylating Perilipin4, and inhibiting GGPP synthase reduces these effects.

Combining Bulk and Single-Cell RNA Sequencing Data to Identify RNA methylation and Autophagy-Related Signatures in Patients with Chronic Obstructive Pulmonary Disease

The paper identifies RNA methylation and autophagy-related genes in COPD using bulk and single-cell RNA sequencing data and validates them in animal models.

Spatiotemporal development of growth and death zones in expanding bacterial colonies driven by emergent nutrient dynamics

This study shows that bacterial colony expansion is driven by mechanical constraints and nutrient gradients, with cell death occurring in a distinct zone due to glucose depletion and anaerobiosis.

Air Pollution Aggravates Renal Ischemia-Reperfusion-Induced Acute Kidney Injury

This study shows that PM2.5 exposure worsens IRI-induced AKI in mice by increasing tubular damage, immune activation, and fibrosis markers.

Doxorubicin inhibits phosphatidylserine decarboxylase and confers broad-spectrum antifungal activity

The paper shows doxorubicin inhibits MoPSD2, a phosphatidylserine decarboxylase in Magnaporthe oryzae, reducing fungal growth and crop disease severity.

Molecular and genetic mechanisms conferring dissolution of dioecy in Diospyros oleifera Cheng

This study identifies molecular and genetic mechanisms underlying the transition from dioecy to monoecy in Diospyros oleifera using genome-wide analyses of 150 accessions.

Curation of the Deep Green list of unannotated green lineage proteins to enable structural and functional characterization

The paper identifies and characterizes unannotated proteins in green lineage species, finding many with novel structures and potential plastid functions.

Transcriptome Analysis of the Nematode Caenorhabditis elegans and Litoditis marina in a Chemically Defined Food Environment

This study compares the transcriptional responses of two nematodes to different diets, finding diet-specific effects on development and lifespan.

Contrasting effects of accumulation and tolerance characteristics in Arabidopsis thaliana under Cr(III) and Cr(VI) stress

This study compares the effects of Cr(III) and Cr(VI) stress on Arabidopsis thaliana, showing Cr(VI) is more toxic due to greater growth inhibition, oxidative stress, and chloroplast damage.

CHARM: COVID-19 Health Action Response for Marines - association of antigen-specific interferon-gamma and IL2 responses with asymptomatic and symptomatic infections after a positive qPCR SARS-CoV-2 test

CHARM study examines T cell responses in asymptomatic and symptomatic SARS-CoV-2 infected Marines, finding persistent IFN-gamma responses to S, N, and M proteins, with higher frequencies to N in asymptomatic cases.

Epidermal Growth Factor Receptor Inhibition Prevents Caveolin-1-dependent Calcifying Extracellular Vesicle Biogenesis

This study shows EGFR inhibition reduces vascular calcification by blocking CAV1-dependent calcifying EV release in CKD mice and humans.

Protein-Metabolite Interactomics Reveals Novel Regulation of Carbohydrate Metabolism

The paper develops the MIDAS platform to identify protein-metabolite interactions, revealing novel regulatory mechanisms in carbohydrate metabolism.

Pancreatic Brsk2 amplifies parasympathetic signals to promote type 2 diabetes

This study shows Brsk2 amplifies parasympathetic signals to promote type 2 diabetes by enhancing β-cell insulin secretion in obese mice and associates human BRSK2 variants with metabolic disorders.

Genome-wide association study reveals the genetic architecture of 27 yield-related traits in tomato

This study identifies 129 loci associated with 27 yield-related traits in tomato, explaining 8.8% of phenotypic variance, and highlights a candidate gene involved in leaf stomata formation and drought resistance.

Structure and allosteric regulation of human IDH3 holoenzyme

This study reports the structure of human IDH3 holoenzyme and identifies key residues and domains involved in its assembly and allosteric regulation.

A Genetically Encoded Trimethylsilyl 1D 1H-NMR Probe for Conformation Change in Large Membrane Protein Complexes

The paper introduces a genetically encoded 1D 1H-NMR probe for studying conformational changes in large membrane protein complexes, demonstrating its effectiveness with minimal protein and time.

PulseDIA: in-depth data independent acquisition mass spectrometry using enhanced gas phase fractionation

PulseDIA improves DIA-MS specificity and sensitivity by using gas phase fractionation, achieving higher protein identification rates in cancer proteomics.

Integrated single-cell transcriptomics and chromatin accessibility analysis reveals novel regulators of mammary epithelial cell identity

The paper integrates single-cell transcriptomics and chromatin accessibility analysis to identify novel regulatory elements in mouse mammary epithelial cells and their differentiation states.

Selective Activation of TASK-3-containing K+ Channels Reveals Their Therapeutic Potentials in Analgesia

The paper identifies CHET3, a selective TASK-3 activator, and demonstrates its analgesic effects in pain models, highlighting TASK-3 as a novel non-opioid analgesic target.