PD-1 expression during acute infection is repressed through 1 a LSD1- Blimp-1 axis
A. P. R. Bally, D. Neeld, P. Lu, P. Majumder, Y. Tang, B. Barwick, Q. Wang, J. Boss
This study shows that LSD1, recruited by Blimp-1, represses PD-1 expression during acute infection by removing activating histone marks and is necessary for remethylation of the Pdcd1 locus.
bioRxiv · May 23, 2019Immunology