P. Lu

Antigen specificity shapes antibody functions in tuberculosis.

This study shows antigen specificity shapes antibody functions in tuberculosis, with different subclasses and targets affecting disease outcomes through Fc effector mechanisms.

Selective degradation of multimeric proteins via chemically induced proximity to TRIM21

This study identifies acepromazine as a compound that selectively degrades multimeric proteins via TRIM21 activation, offering a new strategy for targeting disease-related protein assemblies.

Potential clinical value and influence of conductivity in conductive cardiac patches for reducing post-MI arrythmia risks

This study evaluates the clinical value of conductive cardiac patches by testing different conductivities and shows that higher conductivity reduces arrhythmia risks in post-MI hearts.

Multilevel regulation of NF-kappa B signaling by NSD2 suppresses Kras-driven pancreatic tumorigenesis

This study shows NSD2 acts as a tumor suppressor in Kras-driven pancreatic cancer by regulating NF-kappa B signaling through multiple mechanisms.

Diverging maternal and infant cord antibody functions from SARS-CoV-2 infection and vaccination in pregnancy

This study compares maternal and infant cord antibody responses to SARS-CoV-2 infection and vaccination during pregnancy, finding differences in neutralizing activity, Fc effector functions, and glycosylation patterns.

Enhancing extracellular vesicle cargo loading and functional delivery by engineering protein-lipid interactions

This study shows how engineering protein-lipid interactions can improve the loading and delivery of protein cargo into extracellular vesicles for therapeutic applications.

Omicron Spike Protein Is Vulnerable to Reduction

This study shows that Omicron SARS-CoV-2 spike proteins are more susceptible to reduction due to mutations in the receptor binding module, which affects their stability and binding activity.

Arabidopsis MLO4 Functions as a Ca2+ Channel Essential for Mechanosensing in Root Tips

This study identifies MLO4 as a Ca2+ channel essential for mechanosensing in Arabidopsis root tips, linking touch stimulation to Ca2+ elevation.

Allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv enhance anti-HIV activity in vitro

This study develops allogeneic gene-edited HIV-specific CAR-T cells secreting PD-1 blocking scFv, showing enhanced anti-HIV activity in vitro compared to autologous CAR-T cells.

Interfered Chromosome Pairing Promotes Meiosis Instability of Autotetraploid Arabidopsis by High Temperatures

This study shows that increased temperatures disrupt meiotic stability in autotetraploid Arabidopsis by interfering with chromosome pairing and crossing-over.

A Systematic and Consistent Assay for High-throughput Characterization of Stalk Quality in Sugarcane by Near-infrared Spectroscopy

This study develops a high-throughput method using near-infrared spectroscopy to assess sugarcane stalk quality, achieving high prediction accuracy with RPD values up to 6.3.

Repopulating Kupffer Cells Originate Directly from Hematopoietic Stem Cells

This study shows that repopulating Kupffer cells in adult mice originate directly from hematopoietic stem cells, not from preexisting Kupffer cells or monocytes.

Neuroinvasion of SARS-CoV-2 in human and mouse brain

This study investigates SARS-CoV-2 neuroinvasion in human and mouse brains using organoids, in vivo models, and autopsies, finding evidence of neuronal infection and its consequences.

Detection of SARS-CoV-2 RNA by multiplex RT-qPCR

This paper develops a multiplex RT-qPCR assay for SARS-CoV-2 detection that uses existing primer/probe sets and reduces reagents, costs, time, and labor compared to singleplex assays.

Mouse model of SARS-CoV-2 reveals inflammatory role of type I interferon signaling

This paper develops a mouse model of SARS-CoV-2 using AAV-mediated hACE2 expression, showing type I interferons fail to control viral replication and drive pathology.

PD-1 expression during acute infection is repressed through 1 a LSD1- Blimp-1 axis

This study shows that LSD1, recruited by Blimp-1, represses PD-1 expression during acute infection by removing activating histone marks and is necessary for remethylation of the Pdcd1 locus.

Leptin deficient rats develop nonalcoholic steatohepatitis with unique disease progression

This study characterizes LepΔI14/ΔI14 rats as a NASH model through long-term transcriptomic analysis, revealing unique disease progression and gene expression patterns.

Single-Cell RNA Sequencing Reveals Regulatory Mechanism for Trophoblast Cell-Fate Divergence in Human Peri-Implantation Embryo

The paper uses single-cell RNA sequencing to identify TBX3 as a key regulator of trophoblast differentiation during human peri-implantation development.

Molecular Mapping Of YrTZ2, A Stripe Rust Resistance Gene In Wild Emmer Accession TZ-2 And Its Comparative Analyses With Aegilops tauschii

The paper identifies and maps the stripe rust resistance gene YrTZ2 in wild emmer wheat and compares its genomic region with Aegilops tauschii.

Latent-Based Imputation of Laboratory Measures from Electronic Health Records: Case for Complex Diseases

The paper improves imputation of missing lab measures in IBD EHR data using latent-based analysis and clustering of comorbidities.