The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria
L. T. Wang, N. K. Hurlburt, A. Schon, B. J. Flynn, L. S. Pereira, M. Dillon, Y. Flores-Garcia, B. Bonilla, F. Zavala, A. H. Idris, J. R. Francica, M. Pancera, R. A. Seder
This study shows that the L9 antibody's light chain is essential for binding PfCSP minor repeats and enhancing neutralization of malaria sporozoites.
bioRxiv · Aug 11, 2021Immunology