F. Zavala

Affinity-matured homotypic interactions induce spectrum of PfCSP-antibody structures that influence protection from malaria infection

The paper analyzes structural and functional properties of antibodies targeting PfCSP, showing how homotypic interactions and affinity maturation influence protection against malaria.

A vaccine targeting the L9 epitope of the malaria circumsporozoite protein confers protection from blood-stage infection in a mouse challenge model

This study shows that a vaccine targeting the L9 epitope of CSP in Plasmodium falciparum provides protection against blood-stage malaria in mice.

The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

This study shows that the L9 antibody's light chain is essential for binding PfCSP minor repeats and enhancing neutralization of malaria sporozoites.

A Vaccine Composed of Antigen Fused to a Ligand for a Receptor on Immature Dendritic Cells Elicits Elevated Antibody Responses to Malaria Sporozoites in Infant Macaques

This study shows that a malaria vaccine with a specific antigen and adjuvant induces strong antibody responses in infant macaques, reducing sporozoite load and suggesting potential for human use.

An Epitope-based Malaria Vaccine Targeting the Junctional Domain of Circumsporozoite Protein

This paper develops a malaria vaccine targeting the CIS43 epitope on CSP using Qβ VLPs, showing high immunogenicity and partial protection in mice and macaques.

Structural and biophysical correlation of anti-NANP antibodies with in vivo protection against P. falciparum

The paper analyzes eight anti-NANP antibodies from a malaria vaccine trial, linking their structural and biophysical properties to in vivo protection against P. falciparum.