Author

A. Schon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Organism:human· 3 Assay:proteomics· 3 Research Focus:protein folding & dynamics· 2 Organism:virus· 2 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1

Frequent Co-Authors

A. H. Idris· 2 shared B. Zhang· 2 shared M. Dillon· 2 shared P. D. Kwong· 2 shared R. A. Seder· 2 shared A. Beck· 1 shared A. Chandran· 1 shared A. Finzi· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

A. H. Idris

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

In Silico Improvement of Highly Protective Anti-Malarial Antibodies

M. Mateo, P. Tripathi, L. Da Silva Pereira, P. Kiyuka, T. Liu, B. Zhang, Y. Yang, B. G. Bonilla, M. Dillon, M. Lee, C.-H. Shen, A. Schon, S. Kratochvil, F. D. Batista, A. H. Idris, , R. Rawi

The paper improves an anti-malarial antibody using an in silico pipeline, resulting in a variant with higher binding affinity and better malaria protection.

bioRxiv · Apr 8, 2022 · PreprintImmunology

The light chain of the L9 antibody is critical for binding circumsporozoite protein minor repeats and preventing malaria

L. T. Wang, N. K. Hurlburt, A. Schon, B. J. Flynn, L. S. Pereira, M. Dillon, Y. Flores-Garcia, B. Bonilla, F. Zavala, A. H. Idris, J. R. Francica, M. Pancera, R. A. Seder

This study shows that the L9 antibody's light chain is essential for binding PfCSP minor repeats and enhancing neutralization of malaria sporozoites.

bioRxiv · Aug 11, 2021Immunology

Impact of temperature on the affinity of SARS-CoV-2 Spike for ACE2

J. Prevost, J. Richard, R. Gasser, S. Ding, C. Fage, S. P. Anand, D. Adam, N. Gupta Vergara, A. Tauzin, M. Benlarbi, S. Y. Gong, G. Goyette, A. Prive, S. Moreira, H. Charest, , A. Finzi

This study investigates how temperature affects SARS-CoV-2 Spike protein affinity for ACE2, finding increased binding at low temperatures, which is mitigated by the N501Y mutation.

bioRxiv · Jul 9, 2021 · PreprintMicrobiology

Cryo-EM Structures Delineate a pH-Dependent Switch that Mediates Endosomal Positioning of SARS-CoV-2 Spike Receptor-Binding Domains

T. Zhou, Y. Tsybovsky, A. S. Olia, J. Gorman, M. A. Rapp, G. Cerutti, G.-Y. Chuang, P. S. Katsamba, A. Nazzari, J. M. Sampson, A. Schon, P. D. Wang, J. Bimela, W. Shi, I.-T. Teng, , P. D. Kwong

This paper uses cryo-EM to show how SARS-CoV-2 spike protein undergoes pH-dependent structural changes that affect ACE2 binding and antibody evasion.

bioRxiv · Jul 4, 2020 · PreprintImmunology

Targeting the Pregnane X Receptor Using Microbial Metabolite Mimicry

Z. Dvorak, F. Felix Kopp, C. M. Costello, J. S. Kemp, H. Li, A. Vrzalova, M. Stepankova, I. Iveta Bartonkov, K. Poulikova, B. Vyhlidalova, L. U. Nordstroem, C. Karunaratne, H. Ranhotra, K. S. Mun, A. P. Naren, , R. B. Sartor

This paper develops FKK6, a non-cytotoxic PXR agonist derived from microbial metabolite mimicry, which reduces inflammation and validates the strategy for drug discovery.

bioRxiv · Jan 3, 2020Biochemistry