S. Ganesan

Improved prediction of stabilizing mutations in proteins by incorporation of mutational effects on ligand binding

The paper improves stabilizing mutation prediction by combining computational methods with experimental data, achieving higher precision and thermal stability increases.

Organ specific microenvironmental MR1 expression in cutaneous melanoma

The paper examines organ-specific microenvironmental MR1 expression in cutaneous melanoma using zebrafish models and imaging techniques, finding differential immune responses and metabolism in brain versus skeletal metastases.

Breast Cancer Macrophage Heterogeneity and Self-renewal are Determined by Spatial Localization

This study identifies spatial localization as a key determinant of macrophage heterogeneity and self-renewal in breast cancer, with implications for therapeutic strategies.

Distinct functions of EHMT1 and EHMT2 in cancer chemotherapy and immunotherapy

This study shows EHMT1 and EHMT2 have distinct roles in cancer therapy, with EHMT1 affecting DNA replication and alkylating agents, while EHMT2 influences immunotherapy response via STING expression.

Chemokine positioning determines mutually exclusive roles for their receptors in extravasation of pathogenic human T cells

This study identifies that chemokine receptors on pathogenic human T cells have mutually exclusive roles in extravasation, with CCR6 mediating arrest and CCR2 enabling transendothelial migration through distinct ligand interactions.

Differential metabolic adaptations define responses of winner and loser oncogenic mutant stem cells in skin epidermis in vivo

The paper investigates metabolic adaptations in winner and loser oncogenic mutant stem cells in skin epidermis, revealing distinct metabolic strategies that drive cell competition outcomes.

Single-cell multi-omics defines the cell-type specific impact of splicing aberrations in human hematopoietic clonal outgrowths

This study introduces GoT-Splice, a multi-omics method to analyze splicing aberrations in human hematopoietic cells, revealing cell-type specific effects of SF3B1 mutations in clonal outgrowths.

Integrated Single-Cell Genotyping and Chromatin Accessibility Charts JAK2V617F Human Hematopoietic Differentiation

This paper develops GoT-ChA to link genotypes to chromatin accessibility in single cells, revealing JAK2V617F mutation-induced epigenetic changes in hematopoietic differentiation.

Enhancing Polysaccharide Immunity through Intranasal Immunizations

This study evaluates a polysaccharide conjugate vaccine with NE01 adjuvant for intranasal immunization, showing robust IgG/IgA responses and enhanced Th1/Th2/Th17 immunity against S. pneumonia.

Intranasal Nanoemulsion Adjuvanted S-2P Vaccine Demonstrates Protection in Hamsters and Induces Systemic, Cell-Mediated and Mucosal Immunity in Mice

This study shows an intranasal nanoemulsion-adjuvanted S-2P vaccine induces strong systemic, cell-mediated, and mucosal immunity in mice and protects hamsters from SARS-CoV-2 infection.

Protection of Hamsters Challenged with SARS-CoV-2 after Two Doses of MVC-COV1901 Vaccine Followed by a Single Intranasal Booster with Nanoemulsion Adjuvanted S-2P Vaccine

This study shows that a two-dose intramuscular vaccine followed by an intranasal booster provides strong protection against SARS-CoV-2 in hamsters, reducing viral load and disease symptoms.

Systematic analysis of membrane contact sites in Saccharomyces cerevisiae uncovers modulators of cellular lipid distribution

The paper systematically analyzes membrane contact sites in yeast to identify new proteins involved in lipid distribution.

G2 stem cells orchestrate time-directed, long-range coordination of calcium signaling during skin epidermal regeneration

The paper uses a new machine learning tool to analyze calcium signaling dynamics in epidermal stem cells during regeneration, revealing that G2 stem cells coordinate long-range signaling through gap junctions.

Gradual differentiation uncoupled from cell cycle exit generates heterogeneity in the epidermal stem cell layer.

The paper shows that epidermal stem cells undergo gradual differentiation without exiting the cell cycle, generating heterogeneity in the stem cell layer.

Nanodroplet-Benzalkonium Chloride Formulation Demonstrates In Vitro and Ex Vivo Broad-Spectrum Antiviral Activity Against SARS-CoV-2 and Other Enveloped Viruses

Arsenic trioxide resistance in acute promyelocytic leukemia: More to it than PML mutations

This study identifies metabolic rewiring as a mechanism of arsenic trioxide resistance in APL and shows that combining ATO with mitocans can overcome resistance.

Novel function acquired by the Culex quinquefasciatus mosquito D7 salivary protein enhances blood feeding on mammals

This paper identifies a novel ADP-binding function in CxD7L1, a D7 salivary protein from Culex quinquefasciatus mosquitoes, which enhances blood feeding by scavenging ADP to inhibit platelet aggregation.

IRAK1-mediated coincidence detection of microbial signals licenses inflammasome activation

This study identifies IRAK1-mediated supramolecular organizing centers that coordinate multiple immune pathways to license inflammasome activation in response to microbial signals.

Accelerating iterative deconvolution and multiview fusion by orders of magnitude

This paper introduces faster deconvolution and multiview fusion methods, achieving speedups of 10 to several thousand-fold over previous approaches.

A Quasi Birth-and-Death Model For Tumor Recurrence

This paper introduces a Quasi Birth-and-Death model to predict tumor recurrence dynamics and shows it aligns with clinical data on ovarian cancer.

The Dot/Icm-translocated effector LegC4 potentiates cytokine-mediated restriction of Legionella within accidental hosts.

This study shows that the Legionella effector LegC4 enhances cytokine-mediated restriction of Legionella replication in macrophages.