Extracellular vesicles carrying HIV-1 Nef induce trained immunity in myeloid cells
L. Dubrovsky, B. Brichacek, N. M. Prashant, T. Pushkarsky, N. Mukhamedova, D. Dragoljevic, M. Fitzgerald, A. Horvath, A. J. Murphy, D. Sviridov, M. I. Bukrinsky
The paper shows that HIV-1 Nef-containing extracellular vesicles induce trained immunity in myeloid cells through epigenetic changes and lipid raft upregulation, leading to persistent inflammation.
bioRxiv · Jun 24, 2022 · PreprintImmunology