Targeted Protein Degradation through Recruitment of the CUL4A Complex Adaptor Protein DDB1
M. Meyers, S. Cismoski, A. Panidapu, B. Chie-Leon, D. K. Nomura
This study identifies a covalent recruiter targeting DDB1 for PROTAC applications, enabling degradation of BRD4 and androgen receptor.
bioRxiv · Aug 11, 2023 · PreprintBiochemistry