Author

C.-M. Ho

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:cryo-EM· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Organism:plant (other)· 1

Frequent Co-Authors

A. Bermingham· 2 shared A. Frommlet· 2 shared A. Lingel· 2 shared A. O. Frank· 2 shared A. Ruzin· 2 shared B. Benton· 2 shared C. J. Balibar· 2 shared C. M. Baxter Rath· 2 shared

Activity by Year

2019-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersBiochemistry

A. Bermingham

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Multiscale effects of perturbed translation dynamics inform antimalarial design

L. Anton, W. Cheng, M. Haile, D. W. Cobb, X. Zhu, L. Han, E. Li, A. Nair, C. L. Lee, H. Ke, G. Zhang, E. H. Doud, C.-M. Ho

The paper determines in situ structures of Pf80S ribosomes in Plasmodium falciparum-infected erythrocytes, identifies a bifurcation in translation elongation, and links perturbations to inhibitor effects on ribosome interactions.

bioRxiv · Sep 3, 2023Biophysics

Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition

C.-M. Ho, J. Jih, M. Lai, X. Li, D. Goldberg, J. R. Beck, H. Zhou

The paper determines the native structure of the RhopH complex from malaria parasites using cryo-EM and mass spectrometry, revealing insights into its assembly and trafficking.

bioRxiv · Jan 10, 2021Biophysics

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis

W. Han, X. Ma, C. J. Balibar, C. M. Baxter Rath, B. Benton, A. Bermingham, F. Casey, B. Chie-Leon, M.-K. Cho, A. O. Frank, A. Frommlet, C.-M. Ho, P. S. Lee, M. Li, A. Lingel, , T. Uehara

The paper identifies two distinct mechanisms by which small molecules inhibit LpxA acyltransferase, a key enzyme in lipopolysaccharide biosynthesis.

bioRxiv · Dec 17, 2019 · PreprintBiochemistry

Two distinct mechanisms of small molecule inhibition of LpxA acyltransferase essential for lipopolysaccharide biosynthesis

W. Han, X. Ma, C. J. Balibar, C. M. Baxter Rath, B. Benton, A. Bermingham, F. Casey, B. Chi-Leon, M.-K. Cho, A. O. Frank, A. Frommlet, C.-M. Ho, P. S. Lee, M. Li, A. Lingel, , T. Uehara

This study identifies two small-molecule inhibitors of LpxA, revealing distinct inhibition mechanisms and highlighting compound 2's improved properties for antibacterial development.

bioRxiv · Dec 14, 2019 · PreprintBiochemistry