Molecular mechanisms of fentanyl mediated β-arrestin biased signaling
P. W. de Waal, J. Shi, E. You, X. Wang, K. Melcher, Y. Jiang, H. E. Xu, B. Dickson
This paper investigates how fentanyl activates the mu-opioid receptor through beta-arrestin biased signaling using molecular dynamics simulations and validates findings with synthesized compounds.
PLOS Computational Biology · Apr 10, 2020Peer-reviewedBiophysics