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2 papers
Recent·Most cited
B. E. Danielsson, B. G. Abraham, E. Mantyla, J. I. Cabe, C. R. Mayer, A. Rekonen, F. Ek, D. E. Conway, T. O. Ihalainen
This study develops a nanobody-based FRET biosensor to measure mechanical strain on nuclear lamins and identifies factors influencing nuclear lamina forces.
bioRxiv · Mar 7, 2022Biophysics
B. E. Danielsson, H. C. Peters, K. Bathula, L. M. Spear, N. A. Noll, K. N. Dahl, D. E. Conway
This study shows that progerin-expressing endothelial cells and those with ZMPSTE24 knockdown cannot adapt to shear stress, leading to cell loss, while wild-type lamin A overexpression also impairs adaptation.
bioRxiv · Aug 20, 2021Biophysics