BiophysicsbioRxiv
Progerin-Expressing Endothelial Cells are Unable to Adapt to Shear Stress
B. E. Danielsson, H. C. Peters, K. Bathula…·D. E. Conway
This study shows that progerin-expressing endothelial cells and those with ZMPSTE24 knockdown cannot adapt to shear stress, leading to cell loss, while wild-type lamin A overexpression also impairs adaptation.
DOI 10.1016/j.bpj.2022.01.004