Intravenous gene transfer throughout the brain of infant Old World primates using AAV
M. R. Chuapoco, N. Flytzanis, N. Goeden, J. C. Octeau, K. M. Roxas, K. Y. Chan, J. Scherrer, J. Winchester, R. J. Blackburn, L. J. Campos, C. M. Arokiaraj, T. F. Miles, M. J. Jang, J. Vendemiatti, B. E. Deverman, , V. Gradinaru
This paper introduces AAV.CAP-Mac, an engineered AAV variant that enables efficient systemic brain-wide gene delivery in infant Old World primates.
bioRxiv · Jan 8, 2022Bioengineering