Role of 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase-3 in Maintaining Redox Homeostasis and DNA Repair in Non-Small Cell Lung Cancers Under EGFR-Targeting Therapy
N. Lypova, S. M. Dougherty, B. F. Clem, J. Feng, X. Yin, X. Zhang, X. Li, J. A. Chesney, Y. Imbert-Fernandez
This study shows that inhibiting PFKFB3 enhances the effectiveness of EGFR-TKIs by disrupting metabolic adaptations and DNA repair in drug-tolerant lung cancer cells.
bioRxiv · Mar 25, 2024 · PreprintCancer Biology