X. Yin

This paper shows that enolase inhibitors, specifically HEX, are effective against Naegleria fowleri by inhibiting its glycolytic pathway and extending survival in infected rodents.

This study identifies CPAF-mediated degradation of SLC7A11 as a mechanism for Chlamydia-induced ferroptosis, promoting bacterial dissemination and suggesting therapeutic targeting.

This study evaluates the cytotoxicity and infiltration of CAR-M using 3D tumor spheroids assembled with DNA origami, showing enhanced invasion and killing capacity in 3D models.

The paper identifies a large, non-selective ionic current in mitochondria, called LUNA, which increases during cardiac injury and is inhibited by amiloride.

This study evaluates T1 and T2 mapping for assessing liver fibrosis in mice, finding they correlate with fibrosis stages and collagen/protein markers.

This study identifies two novel oxysterol sulfates in zebrafish skin that function as alarm substances, inducing anti-predator behaviors and increasing cortisol levels at sub-nanomolar concentrations.

This study identifies ARF6 as a novel activator of HIF-2alpha in pulmonary arterial hypertension and shows that the antibiotic CTC inhibits this pathway.

The paper identifies a myeloid-mesenchymal crosstalk pathway involving Arg1 and ornithine that drives profibrotic metabolism in lung fibrosis.

This study identifies glycomic alterations in HIV-positive individuals that correlate with accelerated aging and comorbidities, suggesting potential biomarkers for early detection.

This study shows that STING V154M mutation in non-hematopoietic cells activates autoreactive lymphocytes, leading to autoantibodies and lung inflammation in mice, mirroring SAVI in humans.

This study uses single-cell spatial transcriptomics and optimal transport analysis to reveal therapy-induced changes in pancreatic cancer microenvironment interactions.

The paper identifies UBR4 as a critical mediator of protein interactome homeostasis in aneuploid cancers, showing its inactivation causes proteotoxic stress and convergence of copy number and protein levels.

The paper investigates metal-driven anaerobic methane oxidation in cold seep sediments, finding that Fe-AOM and Mn-AOM contribute ~3% to methane removal.

The paper uses multi-omics data to identify gut microbiome and metabolite markers of immunotherapy resistance in MSI-H/dMMR gastrointestinal cancer patients and develops a predictive model with 0.83 accuracy.

This study modifies human tendon stem cells to enhance graft ligamentation and tendon-bone healing after ACL reconstruction, showing improved recovery in animal models.

This paper describes a method for 3D positioning of DNA origami structures on nano-patterned substrates, enabling scalable and versatile fabrication of complex 3D surfaces.

This paper shows that alpha-ketobutyrate extends lifespan and healthspan in C. elegans and mice by activating AMPK through MACF1/VAB-10.

This study uses human blood vessel organoids to show that CTGF is critical for maintaining microvascular integrity under metabolic stress.

This study shows that the T60 variant of CARD8 inhibits NLRP1 inflammasome activation by interacting with NLRP1 and preventing inflammasome assembly.

This study identifies a compound that induces a persister state in melanoma cells, promoting differentiation and sensitizing them to a prodrug, offering a dual-target strategy for treatment.

This study identifies fermentation of macromolecules as the dominant energy source for microorganisms in gas hydrate-bearing subseafloor sediments.

This study engineers macrophages to inducibly secrete TRAIL in response to the tumor microenvironment, showing improved anti-tumor effects and reduced side effects in preclinical models.

This study shows that PPAR-γ activation with rosiglitazone reduces oxidative stress and promotes xenograft regeneration in a dental follicle cell model.

This study identifies LIPA as a key regulator of CE hydrolysis in cancer cells, showing that its inhibition suppresses metastasis via suppression of NF-κB signaling.

This study identifies Jeholornis as the earliest known frugivorous bird, providing evidence for bird-mediated seed dispersal during the Early Cretaceous.

This study identifies acetylation as a regulatory mechanism in antibiotic resistance in E. coli, showing it negatively affects metabolism but positively influences motility, with PykF acetylation playing a key role.

This study examines how sub-lethal abiotic stresses affect 12 phenotypic traits in Arabidopsis thaliana, finding additive and interactive effects across different stress combinations and accessions.

This study shows that EFHD1 deletion reduces mitochondrial Ca2+ overload and ROS production, protecting cardiomyocytes from ischemia-induced injury.

This study shows drought has a greater impact than growth temperature on wheat leaf respiration temperature response and highlights the inaccuracy of the Kok method for estimating respiration.

The paper develops a fluorescent polarization assay to screen SARS-CoV-2 fusion inhibitors, showing effective inhibitors with sub-mM concentrations and validating the assay with a high Z factor.