B. Fromenty

The dithiocarbamate pesticides maneb and mancozeb disturb the metabolism of lipids and xenobiotics in an in vitro model of metabolic dysfunction-associated steatotic liver disease

This study shows that maneb and mancozeb disrupt lipid and xenobiotic metabolism in HepaRG cells, especially when exposed to fatty acids.

Low concentrations of ethylene bisdithiocarbamate pesticides maneb and mancozeb impair manganese and zinc homeostasis to induce oxidative stress and caspase-dependent apoptosis in human hepatocytes

This study shows that low concentrations of maneb and mancozeb, Mn-containing fungicides, disrupt Mn and Zn homeostasis, induce oxidative stress, and cause caspase-dependent apoptosis in human hepatocytes.