Low concentrations of ethylene bisdithiocarbamate pesticides maneb and mancozeb impair manganese and zinc homeostasis to induce oxidative stress and caspase-dependent apoptosis in human hepatocytes
K. Petitjean, Y. Verres, S. Bristeau, C. Ribault, C. Aninat, C. Olivier, P. Leroyer, M. Ropert, O. Loreal, O. Herault, L. Amalric, N. Baran, B. Fromenty, A. Corlu, P. Loyer
This study shows that low concentrations of maneb and mancozeb, Mn-containing fungicides, disrupt Mn and Zn homeostasis, induce oxidative stress, and cause caspase-dependent apoptosis in human hepatocytes.
bioRxiv · Jul 11, 2023Pharmacology & Toxicology