Pharmacology & ToxicologybioRxiv
Low concentrations of ethylene bisdithiocarbamate pesticides maneb and mancozeb impair manganese and zinc homeostasis to induce oxidative stress and caspase-dependent apoptosis in human hepatocytes
K. Petitjean, Y. Verres, S. Bristeau…·P. Loyer
This study shows that low concentrations of maneb and mancozeb, Mn-containing fungicides, disrupt Mn and Zn homeostasis, induce oxidative stress, and cause caspase-dependent apoptosis in human hepatocytes.
DOI 10.1016/j.chemosphere.2023.140535