TGFβ restricts T cell function and bacterial control within the tuberculous granuloma
B. Gern, K. N. Adams, C. R. Plumlee, C. R. Stoltzfus, L. Shehata, K. Busman-Sahay, S. G. Hansen, M. K. Axthelm, L. J. Picker, J. D. Estes, K. B. Urdahl, M. Y. Gerner
This study shows that TGFβ suppresses T cell function and bacterial control in tuberculous granulomas by inhibiting IFNγ production in T helper 1 cells.
bioRxiv · Jul 9, 2019Immunology